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John Yu-Chih Chang Selected Research

cyclen

7/2013Cross-bridged cyclen or cyclam Co(III) complexes containing cytotoxic ligands as hypoxia-activated prodrugs.
8/2011N-alkylated cyclen cobalt(III) complexes of 1-(chloromethyl)-3-(5,6,7-trimethoxyindol-2-ylcarbonyl)-2,3-dihydro-1H-pyrrolo[3,2-f]quinolin-5-ol DNA alkylating agent as hypoxia-activated prodrugs.
12/2010Syntheses of 8-quinolinolatocobalt(III) complexes containing cyclen based auxiliary ligands as models for hypoxia-activated prodrugs.

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John Yu-Chih Chang Research Topics

Disease

3Hypoxia (Hypoxemia)
07/2013 - 12/2010

Drug/Important Bio-Agent (IBA)

3ProdrugsIBA
07/2013 - 12/2010
3cyclenIBA
07/2013 - 12/2010
2CobaltIBA
07/2013 - 08/2011
2Alkylating AgentsIBA
07/2013 - 08/2011
2LigandsIBA
07/2013 - 12/2010
1cyclamIBA
07/2013
1Oxygen (Dioxygen)IBA
07/2013
1DNA (Deoxyribonucleic Acid)IBA
08/2011